METABOLIC PATHWAYS DATABASES

BRENDA, the enzyme database, has comprehensive information on enzymes and enzymatic reactions. It is one of several databases nested within the metabolic pathway database set of the SRS5 sequence retreival system at EBI. 

KEGG Metabolic Pathways include graphical pathway maps for all known metabolic pathways from various organisms. Ortholog group tables, containing conserved, functional units in a molecular pathway or assembly as well comparative lists of genes for a given functional unit in different organisms, are also available.

The WIT Metabolic Reconstruction project produces metabolic reconstructions for sequenced, or partially sequenced, genomes. It currently provides a set of over 25 such reconstructions in varying states of completion. Over 2900 pathway diagrams are available, associated with functional roles and linked to ORFs.

EcoCyc describes the genome and the biochemical machinery of E. coli. It provides a molecular and functional catalog of the E. coli cell to facilitates system-level understanding. Its Pathway/Genome Navigator user interface visualizes the layout of genes, of individual biochemical reactions, or of complete pathways. It also supports computational studies of the metabolism, such as pathway design, evolutionary studies, and simulations. A related metabolic database is Metalgen.

Boehringer Mannheim - Biochemical Pathways is a searchable database of metabolic pathways, enzymes, substrates and products. Based on a given search, it produces a graphic representation of the relevant pathway(s) within the context of an enormous metabolic map. Neighboring metabolic reactions can then be viewed through links to adjacent maps.